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encephalitis caused by the vaccine strain of measles virus.
[Bitnun A, Shannon P, Durward A,
Rota PA, Bellini WJ, Graham C, Wang E, Ford-Jones EL, Cox P, Becker L, Fearon
M, Petric M, Tellier R.; Department of Critical Care Medicine, The Hospital
for Sick Children, Toronto, Ontario, Canada; Clin Infect Dis 1999 Oct;29(4):855-61]
We report a case of measles inclusion-body
encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5
months after measles-mumps-rubella vaccination. He had no prior evidence
of immune deficiency and no history of measles exposure or clinical disease.
During hospitalization, a primary immunodeficiency characterized by a profoundly
depressed CD8 cell count and dysgammaglobulinemia was demonstrated. A brain
biopsy revealed histopathologic features consistent with MIBE, and measles
antigens were detected by immunohistochemical staining. Electron microscopy
revealed inclusions characteristic of paramyxovirus nucleocapsids within
neurons, oligodendroglia, and astrocytes. The presence of measles virus in
the brain tissue was confirmed by reverse transcription polymerase chain
reaction. The nucleotide sequence in the nucleoprotein and fusion gene regions
was identical to that of the Moraten and Schwarz vaccine strains; the fusion
gene differed from known genotype A wild-type viruses.